Selank is a synthetic peptide developed from a naturally occurring human peptide called tuftsin, which is involved in immune system activity. Researchers modified this peptide to investigate its effects on communication between the nervous and immune systems. Selank has attracted interest for its potential relationship with anxiety-related behaviour, emotional regulation, stress responses, and cognitive function.

Research has examined how Selank may influence brain signalling involved in mood, stress, and emotional balance. Some studies have explored its relationship with GABA, a chemical messenger that helps regulate activity in the nervous system. Other investigations have examined changes in the expression of genes involved in nerve cell communication and immune responses, suggesting that Selank may interact with several biological processes rather than one isolated pathway.

Selank has been studied through laboratory experiments, animal research, and smaller human investigations, primarily in Russia. Some clinical reports have examined anxiety-related symptoms, while preclinical studies have explored behaviour, stress responses, and changes in brain signalling. These findings have contributed to scientific interest in how certain peptides may influence communication between the brain and immune system.

Although Selank has been investigated for several years, its human evidence remains limited by the size, quality, and international availability of published studies. Laboratory findings cannot establish that the same effects occur in people, and the available research does not provide a clear picture of long-term safety or effectiveness. Larger, independently replicated clinical trials are needed to determine its potential significance.